ANSWERS TO PROBLEM SET 5

The page numbers refer to the CBM 2nd Ed..

1. Define oxidation.

ANS:( section 5.1, p.105)

2. Write a balanced half reaction for oxidation of butyric acid to acetic acid.

ANS: (5.2, p. 107)

a. What does that tell us?

ANS: Conversion of butyric acid to acetic acid requires two oxidation steps, 2 water molelcules and a C-C bond cleavage.
b. Write the half reaction for reduction of molecular oxygen to water

ANS: p. 109
c. Combine the two half reactions to obtain the net reactions for the conversion of butyric acid to acetic acid by oxygen.

ANS: p. 109
3. Write a balanced half reaction for the conversion of glucose to pyruvic acid

ANS: p. 108

a. What does tell us?

ANS:Conversion of glucose to pyruvic acid requires two oxidation steps and a C-C bond cleavage.
b. Write the net reaction for the conversion of glucose to pyruvic acid by molecular oxygen.

ANS:

 

 

 

4. Write mechanisms and predict the product for heterolytic oxidation of the following substrates. Use the generic oxidizing agent, A+, for the acceptor (pp. 108-110).
ANS:

a.

 

 

 

 

 

b.

 

 

 

c.

 

 

 

 

 

 

 

 

 

The nucleophile can be water, phosphate, CoA etc.

5. Using the generic catalyst :X=Y-H and the oxidizing agent, A+, write a mechanism for oxidative decarboxylation of pyruvic acid ANS:

 

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