PROBLEM SET 17B-Isoleucine

PROBLEM SET 17B

Isoleucine

 

Isoleucine is an essential amino acid. The structure of the naturally occurring isomer is:

1. Write the structures of the other three isomers and attach the systematic names to all the isomers.

2. Construct a map that shows the possible reactions involved in isoleucine catabolism.

3. Look for the required enzymes in Enzyme Nomenclature (http://www..chem.qmul.ac.uk/lubmb/enzyme. Add these details to your map. Include EC numbers, coenzyme and stereochemistry.

4. Oxidation of 2-methylbutanoyl-CoA gives (E)-2-methylbut-2-enoyl-CoA (tigyl-CoA) instead of 2-ethyl-prop-3-enoyl-CoA. Expplain the chemical basis for this.

5. Consruct a metabolic map that ties isoleucine into the Citric Acid Cycle.

6. Is isoleucine glycogenic, ketogenic or both?

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