The structure of leucine is:


The first three reactions of leucine catabolism are oxidations.

Biotin is required for leucine catabolism. The structure of biotin is:

1. Write the first three reactions of leucine catabolism.

2. What does the biotin requirement tell you?

3. Write a general mechanism for carboxylation at carbon.

4. Based on this information, write two possible pathways for leucine catabolism.

5. How can you decide which of these two pathways actually occurs?

6. Construct a map for leucine catabolism. Include enzymes and coenzymes.

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